Chaos Lord8 wins (3 of them EMs), 2 lossesWidely variable, but generally on the tough side due to mutants, Steals, and Explosions. Put up Hourglasses as Steal/Explosion bait, and save Antimatters for high attack creatures with abilities. Liquid Shadow really annoying mutants (Steal, etc.) and Druids. Protected Permafrost is a good thing here. Decking out could be a problem if you can't destroy his Dissipation Fields.
Dark Matter0 wins (0 of them EMs), 8 lossesInsanely difficult due to Black Hole spamming. If they get a Gravity Nymph when you don't have something to use against it (i.e. Liquid Shadow, Mindgated Quinted Oty, etc.) to use in response, you're doomed. An early Aflatoxin may also help so that it fills their field with Cells, leaving them without any room to place their creatures in. Antimatter the Chargers or Momentumed large creatures. Remember, it's pretty much an auto-loss once a Gravity Nymph comes into play and you don't have an answer for it.
Decay9 wins (6 of them EMs), 1 lossEasy and almost a definite EM if you can get Jade Shield out in time (and have some spare quanta to counteract the Devourers' drain), difficult if you can't. Protect your Pulvy, or have some Hourglasses as bait when you play it -- you don't want it to get stolen, as it's your only defence against Dusk Shield and Eclipse (if you don't have a shield out by then). Early Supernovas are a lifesaver in this match-up.
Destiny5 wins (2 of them EMs), 0 lossesEasy, provided that the AI doesn't get lucky and hatch Dragons/Nymphs from their Fate Eggs. An early shield with a few Shards provides you with a sufficient early defence while you wait for your Quinted Destroyers to appear. Destroy Hourglasses and Eternities with your Pulvy whenever possible so that their drawing doesn't get out of control. Antimatter Chaos Powered creatures or mutants with high attack power. Druids and annoying mutants can be Liquid Shadowed out of the way.
Divine Glory1 wins (0 of them EMs), 11 lossesDifficult, because of all the dead cards in your deck (flying Glories are untargetable), their insane amount of permanent control, and Miracles. Try to hold on to your Shards so that they avoid the initial Explosion spree, or put lots of Hourglasses and Pulvy as bait. Protected Permafrost is very useful for damage reduction, with both its regular shielding ability and its freeze chance. Preventing Miracles is a priority in the late game, since you could end up decking out if you don't time your attacks right. Without Fractal, it's a lot harder to do because the best that Mindgate can do is give you more Flying Weapons and Glories to fly for the final Miracle-avoiding hit. Liquid Shadow your first Destroyer at the end to ensure an easy EM.
Dream Catcher2 wins (1 of them EMs), 11 lossesVariable, but generally quite difficult due to their permanent control on a stick (Butterfly Effect). If they get a Butterflied creature out early, then you're in deep trouble. Use Liquid Shadow on creatures that have been Butterflied or the Physlias. Jade Shield or a protected Permafrost work wonders here. There's nothing really worth Antimattering unless they Hatch something good from a Fate Egg.
Elidnis6 wins (3 of them EMs), 4 lossesPretty easy if you can get an early shield up; Puffer Fish could still be a problem if you can't find your Shards and Permafrost in time. An early Pulvy can destroy Bonds and disrupt their shaky quanta generation by destroying their Towers. Mindgate is amazing if you can grab their Congeals and use them on their own Puffer Fish. Liquid Shadow a Puffer Fish or a small Forest Spectre to get rid of their annoying abilities. Antimatter a large Forest Spectre. Don't try to Antimatter the Pufferfish -- it will only ensure that its poison attack goes through your shields every time. Aflatoxin is a double-edged sword. On one hand, you'll prevent them from playing any more annoying creatures. On the other hand, you may risk decking out if they pull enough Bonds for healing and you can't destroy them quickly enough with Pulvy.
Eternal Phoenix0 win (0 of them EMs), 8 lossesQuite difficult due to Phoenix spamming and Explosions. Jade Shield or a protected Permafrost, along with Antimattered Ruby Dragons will hopefully keep you alive long enough to win. Try to hold on to your Shards so that your Hourglasses, Pulvy (essentially a dead card because there isn't anything worth destroying), and Towers are Explosion bait. The only way for Aflatoxin to be used is if played on a Ruby Dragon (though you'd rather Antimatter it instead), or by using Liquid Shadow first on the Phoenix (to remove its Phoenix ability).
Ferox10 wins (4 of them EMs), 1 lossNot bad if you can get your shield and Shards up in time, but you are prone to being outrushed. Antimatter the Dragons or large Adrenalined creatures, but don't hesitate to use it on the Frogs and Cockatrices if you're on the verge of losing. Alternately, you can Liquid Shadow the Adrenalined ones, or save your LS to use on your own Destroyer at the end for an EM win. Destroy their Bonds with Pulvy. Again, Aflatoxin is a double-edged sword, and even more so than with Elidnis since Ferox has 12 of them. If you can't destroy their Bonds in time, you might deck out.
Fire Queen4 win (0 of them EMs), 8 lossesEasy if you can grab a shield and Shards in the early game. Antimatter flown Eagle's Eyes and Fahrenheits, destroy their Bonds with Pulvy, and use LS on their FFQ to help slow the swarming. Permafrost is amazing in this match-up. The real difficulty is in the endgame, however. Aflatoxin is still a gamble with the threat of decking out if you can't get rid of their Bonds quickly, but their field will be full of Fireflies anyway, so it doesn't matter as much in this situation. Destroy their Bonds quickly, or you might deck out.
Gemini3 win (2 of them EMs), 1 lossNot too bad unless you get outrushed or TU spammed in the late game. Shields up (Permafrost is great here) and Shards will let you survive long enough to bring Destroyers out. An early Aflatoxin used on a Phase Recluse is amazing, as it allows you to fill their field with Cells and prevent TU spamming and also lets you skip Quinting your Destroyers (provided that you have Pulvy out and enough quanta to power it and destroy Electrocutors). Antimatter their Momentumed creatures; Liquid Shadow can be used on Momentumed Recluses in the early game to get rid of them. Make sure that you can find and fuel your Pulvy -- if you can't destroy their Phase Shield chains, you will deck out.
Graviton0 wins (0 of them EMs), 4 lossesInsanely difficult. Momentumed, growing creatures are horrible enough already, but they also have Explosions to make you even angrier. Even the mighty protected Permafrost has problems if too many of their creatures are Momentumed. Use your Antimatters wisely on larger and Momentumed Firemasters, and Liquid Shadow should target opposing creatures with Momentum. As usual with opponents that have large amounts of permanent control, use your Hourglasses and Towers as bait to protect your shields, Shards, and Pulvy. Mindgating a Gravity Shield is very helpful, but you'll want to watch out for sudden applications of Momentum, which will ruin your game.
Hermes1 win (0 of them EMs), 10 lossesInsanely difficult due to the amount of permanent control and rapidly growing creatures. Use your Towers and Hourglasses as Explosion bait while you try to get a Jade Shield or protected Permafrost into play, along with Shards for stalling. Hope that you get lucky with the Permafrost freeze chance -- your survival depends on the RNG. If their Destroyers get frozen, it's a suitable time to apply some Aflatoxin to it while they can't grow. Otherwise, just put it on a Brimstone Eater or Fire Spectre while you hide behind your shield and watch their field fill with Cells). Liquid Shadow is handy for getting rid of Antimatter their Ruby Dragons if you manage to get that far into the game.
Incarnate7 wins (4 of them EMs), 2 lossesPretty easy; you'll survive the early game, but beware of decking out. Antimatter the Vampires for an instant Liquid Antimatter effect. Bonus tip: if you Antimatter the Vampire BEFORE destroying their Eclipse with Pulvy, its attack will go from -6 to -8 when Eclipse is destroyed. Make destroying Eclipses a priority, followed by the Bone Walls -- they will be the bane of your existence in the late game, especially if you can't get Quinted Destroyers out relatively early.
Miracle3 wins (0 of them EMs), 2 lossesPretty easy, though you might get outrushed early or deck out due to Miracle spam if you're unlucky. Destroy their Shields and Light Towers whenever possible to prevent back-to-back Miracles. Antimatter the Dragons or blessed Pegasi -- the Liquid Antimatter combo works well here. Use Mindgate as an improvised Fractal by holding on to all your Mindgated creatures until you can play them all in one turn and win. Watch your damage output carefully; you don't want to deck out due to untimely Miracles.
Morte2 wins (2 of them EMs), 5 lossesHe has both Bone Walls and Miracles, so losses are decking out are much more common than with Miracle and Incarnate, but Morte is still fairly easy. Antimatter the Dragons, and you can Liquid Shadow them if you'd like -- their Archangels are nice enough to keep their Liquid Antimattered Dragons alive for you. You may wish to put a few of your Mindgated creatures on the field to help take out Bone Walls, and then save the rest to use as an improvised Fractal to avoid triggering Miracle.
Neptune14 wins (10 of them EMs), 1 lossVery easy, though you may lose due to getting outrushed by Dragons and Crawlers if the AI gets lucky and you can't get a shield out in time. Permafrost is a wonderful lifesaver. Antimatter goes on the Dragons; feel free to LS them if you want. Otherwise, Neptune's pretty straightforward to play against.
Obliterator10 wins (4 of them EMs), 9 lossesAlmost a coin flip match-up. Draw aggressively for an early Pulvy to destroy incoming opposing Pulvies, and hope that they don't get an early protected Pulvy. If they do get a protected Pulvy out, then protect your Permafrost (or use Jade Shield, though Permafrost works better in this case). Use the Liquid Antimatter combo on their Dragons -- preferably their Momentumed ones.
Octane5 wins (3 of them EMs), 1 lossEasy if you can get Jade Shield up early on, a little bit difficult if you can't. If you don't have Jade yet, destroy their Gases with your Pulvy. Antimatter their flown weapons.
Osiris3 wins (2 of them EMs), 6 lossesEasy if you can find a shield and a Pulvy in time -- Permafrost is ideal in this match-up. Antimatter, Aflatoxin, and Mindgate aren't too useful because of their Scarabs' tendency to eat everything -- including Antimattered/Aflatoxined creatures and Cells! Liquid Shadow or Antimatter a Pharaoh (if it's early enough, so that Scarab production slows down) or a Momentumed creature (in hopes that the Scarabs will eat it). Catapults make him a little more dangerous, but as long as you can get Pulvy out to destroy them before too many Scarabs are launched at you, you're fine.
Paradox2 wins (1 of them EMs), 3 lossesYou could get outrushed early or deck out from Miracles, but it's still fairly easy. Permafrost is amazing here. Antimatter large Deja Vus; if you can get them before they split, the AI will still stupidly split them. Aflatoxin or Liquid Shadow their Rays of Light to minimize

quanta production and therefore the Miracle spamming. If you can fill their field with Cells, then you won't need to Quint your Destroyers. The most difficult part of the duel is probably preventing the Miracle spam at the end.
Rainbow4 wins (2 of them EMs), 6 lossesVery difficult due to the amount of permanent control, and also Miracles if you manage to survive to the endgame. If you can get a Pulvy to survive on the field (through clever Hourglass and Tower baiting), keep destroying their Hourglasses to reduce the amount of draw they have access to. If you can, protect your Permafrost. It's going to be rather difficult to work around Miracle, since the creatures gained from Mindgate require lots of growth time in order to be effective.
Scorpio1 win (0 of them EMs), 7 lossesA little bit easier when you can get Mindgate working early, but it's still a hard match-up. Set up a Permafrost Shield quickly. Antimatter their Dragons, Liquid Shadow their Physalias or Puffer Fish. Mindgate can provide some support if it gives you Congeals to use on their Physalias and Puffers. Pulvy is useful in destroying their weapons and shields.
Seism7 wins (6 of them EMs), 7 lossesHard, but still winnable. Play your Towers one at a time until the AI ends their turn with more than 2

left before quanta generation. Early Supernovas and/or a PA on your Towers makes life much easier. Permafrost is again very useful. Antimatter their Dragons (use the Liquid Antimatter combo on the Basalt Dragons, not the Silurian).