From three Lobotomizers in 30 cards to two Lobotomizers in 35 cards is huge jump. How much harder are the Osiris, Paradox, and Incarnate matchups? I'd consider dropping a Hope and 2 SoG, and adding a Lobo back in.
I'm also interested in how often Decay steals the Sanctuaries. From what I remember, Sanctuary's targeting priority is way up high.