First things first: It seems too expensive. After all, it's very luck-dependent. I'd take this down to 5

and 4

upped.
Secondly: I fully support $$$man's idea. Upgraded version costs 4

and effects you. Oh yes,

and Otyughs with 30 health

Thirdly, I agree with boomclap. This is because area spells (Fire Storm, Lightning, Pandemonium) also don't target immaterials, and Mad Science shouldn't either for consistency's sake.
Fourthly, the unupped version's title is a concept and the upped one is a person. Consistency plox?

Otherwise, great concept and great card.