Jmizzle, I'm ashamed of you. 8)
Mark of Life
6x Genesis
6x Horned Frog
6x Jade Dragon
4x Cockatrice
4x Adrenaline
4x Heal
You chill out for 2 turns, then create 8 Pillars all at once, put them all down, and know that you're never going to waste another turn drawing a useless thingy for the rest of the game.
Alternately:
Mark of Whatever
6x Greater Genesis
(Tight 30 card aggro rainbow deck with no Pillars)
Again: duplicate key cards 3-4 times to prevent yourself from losing all of any one of them to Genesis, and slap out
8 Quantum Towers on Turn 1 -- and get quick, ultrastable quanta prodcution that will let you cast everything you draw for the rest of the game.
Sacrificing the cards in your hand to get the Pillars isn't actually the problem -- because you've got more active cards in your deck overall. The real problem is the speed with which you can acquire new things to cast. But that's part of the balancing act.