Not enough regen. Not enough CARDS (you will end up decking out very often if you regularly use 3 hourglasses in 33 cards). Not enough chips on the key creatures--if you don't draw the OTYUGH, I don't know how you win.
-1 Heal, -1 Pest
+2 Antimatter, +1 Miracle, +2 Otyugh, +1 Rain of Fire, +1 Bone Wall, +1 Quint, +1 Hourglass, +3 Quantum Pillar/Tower, +1 Pulverizer
And you have a 44 card deck. If you don't have another 2 upped otys and 1 extra electrum hourglass, up those first. After that maybe you'd want to look into 2 SoGs before continuing with the rest of the pillars.