I can give you a few I thought of as I was working on this...
Holy Light damage-dump on full-HP creatures. (possibly too powerful)
Angel damage machine, up to 5 per Angel per turn.
with
mark can get extra damage out of Fractal Devourers. Probably impractical. Also make opponents pay through the nose if your vampirism outstrips their damage.
Heal 120-damage dump. (possibly too powerful)
with
mark has various Empathy abuses... maybe Malignant Cells too?
Black Hole, already something of an opening card, becomes a powerhouse.
Antimatter can be effective, but placement and timing are paramount.
Some of these combos do look a bit OP, especially Heal. Imagine precogs, Time mark, novas, life pillars, and Heals. It sounds more devastating than Gas decks.
Not sure how to balance this, dividing it by half sounds good at first but rounding is a problem for stuff like Empathic Bond. Perhaps a flat-rate for each healing effect? Again, problematic with Bonds, but I'm thinking out loud and this is a very raw concept so far.