I *think* it means, you cannot sacrifice the extra ups you get from berserker role, but you can still use your role to get extra upgrades and you can sacrifice the original upgrades, e.g.
1. berserk 2 cards for +3 ups, but sacrifice the original 3 ups => use 3 ups in deck, and get 4.5 relics.
2. berserk 3 cards for +4 ups, but sacrifice 2 of the original ups => use 5 ups in deck and get 3 relics
and many other combinations.