Just a side note: I run -1 Aether Tower, +1 Electrocutor as a hard counter to Fire Queen. The deck can still fail against a super early Owl's Eye/super late Electrocutor, but if you start Lobotomizing within the first 3-5 turns, it's an easy win.
This also hard counters Ferox, provided you get Hope up to 12+ damage reduction.
Miracle is a little more difficult because of Blessings, but still very possible.
Hermes is slightly difficult, but possible. I run a different version with more Salvagers, and you MUST draw an early Electrocutor to prevent Lava Golems from growing to insane amounts of damage.
Should be a pretty good counter to Hecate, but beware of Steal, as that won't trigger salvaging. Maybe a SoP-less, regular RoL/Hope would be better. Also, Hecate WILL Liquid Shadow your RoLs. And Rage Elixirs go right through your Hope.
Can work against Seism, but it all depends on his RT/Quicksand draws. (RT isn't that bad). He has no way of controlling your Shard of Patience, or of piercing your Hope. Once Hope > 13 Damage Reduction, you win. Possibly a trio with Protect Artifacts?
Can counter Eternal Phoenix, but you need more Salvagers. autoloss if he Firestorms too early. The oracle counter on the EtG community wiki is more effective.
Destiny has better counters.
Graviton is extremely difficult due to growing, Unstoppable creatures. And Otyughs. Graviton is the hard counter to this deck. Auto-Quit unless you get a perfect draw can win, which would be: Shard of Patience, Electrocutor, and Phase Salvager. Play all at once. Lobotomize everything that even blinks. But if he gets an early Otyugh, and defends it's skill with Explosions, you lose.
Chaos Lord.. just depends. Mutants with Steal/Destroy will ruin your day. Overall, Poison Dials is a better counter.
Dream Catcher depends, too. I just faced him, and he got a turn five Quint'd Purple Nymph. Ouch.
Scorpio: Hard. That's all. Pretty stinking hard, and we have better counters in the form of Poison Dials.
Serket: Better counters in the form of Poison Dials/Wings/Dimensional Shield, but still possible. A decently early Hope would shut her down completely. I recommend -1 Electrocutor, -1 Aether Tower, +2 Purifies for her. So, this could be modified into a hard-Serket-counter, but why bother when we already have those?
Neptune: Get an Electrocutor out before anything else, Lobotomize any Squids, then make sure you have these three cards in hand: Shard of Patience, Ray of Light, Fractal. Play in that order to win. Once the RoLs have grown beyond 4 HP, and you're lobotomizing all the squids, you win. Well, if you get a Hope. I just lost because of no Hope.
Rainbow: has Steals. I prefer to skip.
Lionheart: Crusader + Eternity... is rage inducing. If he gets that combo out too early, it's an autoquit. If you get tons of RoLs out on the field early, it's probably doable. Idk about Electrocutor here, though.
TL;DR? New Old Times is good against anything the old (or new) Instosis is good against (with a couple exceptions).