Playing mitosis needs
quanta, which you should not be generating (keep
quanta instead) until you played Hope.
So, before Hope, no mito just play as many RoL as you draw, and 1 rustler (but don't use it yet).
Once Hope is out, you can use the rustler and play mito on the RoLs, the AI will focus rewind on non-mito RoLs.