Pseudo-unupped pulvy: Dagger, Butterfly Effect, Antimatter, Blessing, Plate Armor, Rage Potion
EDIT: The above doesn't quite work, Short Sword, Flying Weapon, Antimatter, Butterfly Effect, Blessing, Heavy Armor x2, Rage Potion should! (3|2 becomes -3|2, becomes 0|5, becomes 0|17, becomes 5|12).
Arsenic isn't possible with weapons, but you can do Scorpion, Antimatter, Blessing, Blessing, Plate Armor, Shockwave for upped. Lobotomizer is the same way; upped is Mind Flayer, Blessing.