I'd change the mark to entropy, upgrade 2 novas to super novas, upgrade the vampire and add a lycan in place of that micro abomination. But that's just my opinion..
that would destabilize the whole deck, it's created to only need 3 of each quanta and it's made to have a succefull 33% of getting them in the first 10 cards of the deck, making you able to play everything you draw after, any changes would only be viable if the total cost needed for each element is 3.
Changing mark to entropy would mean that all the quanta created by mark would be wasted from turn 3 till the end of the game, and also not to be able in some cases to use them with fire eaters, the only recurrent quanta users.
Micro abomination are also part of the equation as they are used for cremation.