if you use nova, unupped is an improvement over titanium shield in many ways.
Against creatures that deal 2 or more damage, it effectively blocks as much damage.
Against creatures that only deal 1 damage, this causes healing.
The advantage of titanium shield is that it works better against 'on-hit' effects like vampire;
It will also more often fully block a scorpion, preventing the poisoning.
Still, since 'other' quanta is so much easier to get, it'll be a lot stronger.
And that is not even including cards like aflatoxin or nightmare.