Not sure what color you're running, so I'll just run down the list:
![Aether :aether](https://elementscommunity.org/forum/Smileys/solosmileys/../../../images/Misc/aether18x18.png)
: Most of your hard hitters are immune to freeze (so obviously you aren't an Aether player).
![Air :air](https://elementscommunity.org/forum/Smileys/solosmileys/../../../images/Misc/air18x18.png)
: Use Owl's Eye to destroy his squids.
![Darkness :darkness](https://elementscommunity.org/forum/Smileys/solosmileys/../../../images/Misc/darkness18x18.png)
: Drain Life his squids. You can also be sneaky and use Liquid Shadow on his squids. He'll get a couple points of health back, but it'll kill the squid.
![Death :death](https://elementscommunity.org/forum/Smileys/solosmileys/../../../images/Misc/death18x18.png)
: This color has more creature-destruction options than I'd care to list.
![Earth :earth](https://elementscommunity.org/forum/Smileys/solosmileys/../../../images/Misc/earth18x18.png)
: Earthquake his lands to make that 3-quanta cost all the more punishing.
![Entropy :entropy](https://elementscommunity.org/forum/Smileys/solosmileys/../../../images/Misc/entropy18x18.png)
: Chaos Seed/Pandemonium to try and destroy his Squids. Also, Discord will make it hard for him to want to keep casting.
![Fire :fire](https://elementscommunity.org/forum/Smileys/solosmileys/../../../images/Misc/fire18x18.png)
: Burn, burn, burn.
![Gravity :gravity](https://elementscommunity.org/forum/Smileys/solosmileys/../../../images/Misc/gravity18x18.png)
: Gravity Pull his squids to burn them down.
![Life :life](https://elementscommunity.org/forum/Smileys/solosmileys/../../../images/Misc/life18x18.png)
: As mentioned already, Adrenaline your creatures and they'll break-out much more quickly.
![Light :light](https://elementscommunity.org/forum/Smileys/solosmileys/../../../images/Misc/light18x18.png)
: You should easily be able to out-last him until he decks-out.
![Time :time](https://elementscommunity.org/forum/Smileys/solosmileys/../../../images/Misc/time18x18.png)
: Get your weapon out and start kicking his Squids back into his deck.
![Water :water](https://elementscommunity.org/forum/Smileys/solosmileys/../../../images/Misc/water18x18.png)
: Try to farm-up a few squids and use them to lock-down his squids.
Also, I know that you're talking about a Fractal deck, and a lot of these are single-target. The idea is to kill his Squids before he gets the Fractal out (because you know the AI isn't smart enough to hold a Squid in his hand on purpose so he can drop it and Fractal in one turn). Also, a lot of these cases will let you out-last him while your weapon whittles him down, especially if you're using a shield that renders all the Squids useless for attack.