No it wouldnt make sense.
I would love if buffing a single creature would be a viable strategy, but it just isnt. The real problems are not shields (there are ways to get around those), but Antimatter (bugs with dive dont count), and Rewind - spells that directly screw your strategy up, and you cannot do anything about it but make your creature untargetable by yourself too, thus preventing application of future buffs on said creature.