While I've run into many death decks that use otyughs, I've never run into my specific deck before (If you've run into it, it was probably me
). And I rather enjoy it.
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The general concept is to get a Bone Wall out as soon as possible alongside an Otyugh to slow the opponents deck down, while throwing out as many Sapphire Chargers as possible for damage. It is a slower deck then some, but it's consistent damage (opponent shields are irrelevant), and it's a good deck at frustrating a lot of the quick decks (my success rate on pure death decks is huge, even if it's fully upgraded and you're not). Plague and Momentum are there to help your Otyughs along. Don't be afraid to eat your own Otyughs with another one of your Otyughs when the situation calls for it (IE, you need your Bone Wall larger).
Your first upgrades should be all your Otyughs, as they are your most important card. Second I recommend your Bone Walls, or a mix of Bone Walls and Bone Pillars. Third should be your Sapphire Chargers.