You really should test decks before you post them, not just to see how they work but also to see how viable they are against what opponent. Luckily you've at least packed some Heals to avoid this turning into YASR (yet another slow rush). Now as for how poisonous works with Adrenaline... it activates on the first and last turn, so you only get 2 poison per EpiPuffer (this is also true for Scorpions and Devourer/Pest to prevent overpoweredness). As you also mentioned, it still dies to Lightning and you lose two cards, except now you lost more
because Puffer is more expensive than Frog, but you keep the 2 poison doing damage even if the Puffer dies.
The quanta is unbalanced, and I would suggest using Life mark with Water towers and a few pends. Faster Puffers, stabler quanta.
If you don't have the cards to test a deck you think looks nice, try the
Trainer.
Lastly, since it
seems you haven't played this deck and don't know how it performs, you should post ideas you have in the Deck Help board. It might be a finished concept, but it's not a finished deck.