My opinion on this is that for the Debuff series, the debuffs are represented as status effects, rather than abilities of any kind. For now, most of our other series don't appear to threaten Lobotomizer's power or uniqueness very much at all.
However, I will suggest that we hold back on the Essence series until the discussion settles down a bit, as well as use caution when giving a card the ability to give wedge to creatures.