the only card i can see with viable synergies to this card is nightmare.
the others, like say, fractal, are you really going to discard YOUR fractalled cards to give this card a boost, in favour of say, summoning a bunch of fractalled RoL's for a RoL Hope?
Mindgate synnergy seems useful as well.
I would definitely consider discarding a random card I just got from my opponent in the hopes of being able to play things I get on later turns.
As for fractal... yes, if I had several construction drones out at once, it could be well worth the investment. Is it worth discarding 1 scarab to get back several time towers / pendulums?
With only 1 drone in play it may not be worth it but with several in play this is providing card advantage.
Moreover, this allows fractal to be used to copy the OPPONENT's creatures. You just discard one of them to get the pillars you need to play the rest.
With that in mind, have a look at the cross synergy between the upped and unupped. You essentially get an unlimited (albeit somewhat random) spell source.
Also, it not only synergies with nightmare, it also helps provide a soft counter as well.
Outside of GoTP, simply discarding 1 nightmared creature could yield the quanta source needed to play the rest.
That would make the opponent think twice about what the decide to nightmare to your hand.
There is also SoSe synnergy. Basically, you use SoSe to fill your hand and discard the least useful card. It then provides several pillars which can later be sacrificed to create spells.
Lastly, there is synergy with NT... Just like this provides an unlimited spell source, it would also provide an unlimited pillar source. Which could be very useful there.