CURATOR COMMENT-Leave the ATK|HP section of the table blank if the card is not a creature (n/a is not acceptable)
You do remember that Death creatures also benefit from Eclipse, correct? In this case, giving a creature Infect while also allowing it to benefit from Eclipse is a nice combination, and I can already see the power of this rune combined with Voodoo Dolls (since Voodoo dolls don't lose their passive with this Rune Spell, I can imagine that you can effectively poison the doll using its own Infect ability to rack up poison in a new way >.>).
The permanent ability seems slightly clunky, but I blame it more on the 'pay X life' in addition to the Death quanta you need in order to pay for Miasma. Since this card effectively reduces attack by 1 for all (targetable) creatures, this would have untold synergy with Aflatoxin; intentional, I'm guessing.