Nope, giving antimatter a weakness to himself is not making it more powerful in any way. Weakness doesn't add power. Also antimatter doesn't prevents the creatures from using its ability like insta-kill does.
The antidote for a card, being the card itself makes the card more valuable, thus more powerful. The more important and useful a card is for winning, whether to use on a opponent, or counter something a opponent does, or even more-
both, the more
POWERFUL it is. Useful and effective for winning = Powerful
Creatures usually have a good ability, or lots of attack, not both.
On a creature with no ability Antimatter basically kills the creature for the opponent, and gives it to you. Its damage is subtracted from them, and given to you.(ok, healing, not damage, but it amounts to the same) Antimatter on a card with no ability is TWICE as effective as simply killing the creature would be.
And on a purple nymph can be used over and over for a affordable price.On a creature with no attack, or very little attack, but a good ability, antimatter wouldn't be very effective, but that is what lobotomizing is for. Lobotomize on these creatures effectively kills it, and there is no way to fix it, other then to sabotage your drawing by putting in back on your deck and respending all that energy again. Lobotomize is more effective then slay would be because lobotomize is cheaper, and a ability on a number of cards that can be used multiple times. Another solution to such cards is direct damage spells to simply kill them because such cards do not usually have much HP.
So that leaves voodoo dolls and perhaps 1 or 2 other cards I am not thinking of right now.
There is already-
Explosion: Destroy any permanent (this Slay card, except for the non creatures) for extremely cheap (1),
Steal: Which is an explosion that also boosts you- the antimatter of explosion.
Earthquake: that will destroy up to three pillers/pendulums (card kill that hits 3),
Poseidon: Earth quake that can be used over and over for cheap.
Many direct damage spells that can be used for the low HP stuff. (and with time, high HP ones)
The stuff that can
Lobotomize &
Antimatter: which I already covered.
Face it,
many shades of this idea are already in the game!(but more powerful then this idea)
For that matter, most dragons cost alot of energy, yet have very little HP in comparison to keep them alive, not unreasonable targets for any cheap direct damage spell, especially fire's.
Anyway, put in X damage then like I said earlier.
How about this then- does 4-5 damage for every 10 death quantum you have but only on creatures, a fire Lance that doesn't work on players. I still see no reason it can't potentially strip immortality too. Maybe if you have say 60 or more death quantum when casting it can do that instead of damage.