Yes, I suppose it would have some kind of debuff, which could also be lobotomized.
For Aether: Well being immortal messes up most spells you would want to use on them. You could always target your own creatures. Though, I had thought that creatures with previous abilities would keep them, and that they would apply against creatures. So if you use the card on a Sapphire Charger for example it would keep its Momentum, and that Momentum would then be able to deal damage through the Immortality ability as if it were a shield.
For Adrenaline: Each of those attacks is a different turn so it would have new targets for each attack.
The bold part just brought up a WHOLE new tactic to use with this spell, assuming one is willing to take the risk. Adrenaline might cause a headache for the ones who are coding this (if they ever do), but I suppose it makes sense. I also thought of a good way to counter this card unless it has Momentum on it also:
Gravity Pull.