So how about:
No more copies of the target creature can be spawned.
Consumes all your remaining Death quanta.
This would mean no Scarabs off Pharaoh, no Fireflies off their queen, no creatures off Mitosis, etc. but Mummies, Skeletons, Shriekers, Nymph's Tears and Phoenixes/Ashes would be unaffected since they transform the target rather than spawning anything (though the game mechanics are the same). I'm still undecided on Fate Eggs due to technicality.
Immunity should, IMO, be given only to creatures that it makes sense for. Specifically, Skeletons, Mummies and Malignant Cells.
I like that idea, kind of, but I'd like to argue that FFQ's can still produce offspring. It makes sense that you'd have to make the queen extinct to make the fireflies themselves extinct, but that's probably too complicated to worry about. Lots of things in the game's mechanics don't "make sense" but are probably there becaues they're easier (like Mummies/Skeletons still being poisoned when hit with RT, speaking of that concept...).
After I posted my last post, I realized that Malignant Cells don't make sense to become exinct because they aren't a "living species", so to speak. Of course, Skeletons and Mummies aren't a "living species" either. So you're saying they're immune to extinction? Nice concept. Then you don't have to deal with the Boneyard/Malignant Cell issue. But I think you were replying to my thing about immortality and what I was saying is since "Immortal" creatures can't be
targeted, they shouldn't be able to be targeted by this, either. It makes sense. ALSO, if you DON'T have all creatures already out die, then my 2nd point doesn't matter, but if they do die, and you have, say, an immortal ruby dragon and a regular ruby dragon, and this card is used on the regular ruby dragon, doe sthe immortal one die too?
Other than that, you addressed pretty much all my questions in a short paragraph or 2.