Not quite anything... if the effect used gives Spark a point of defense, it works normally. Anything else kills Spark, even Quintessence.
You can use:
Plate Armor
Momentum
Blessing
on a Spark without killing it.
On the other hand, this bug is handy for producing a Malignant Cell on your turn... Spark, then Aflatoxin, followed by Adrenaline and Quintessence on the Cell before the opponent gets a chance to do anything to it.