Black Hole still restores health (1HP per quantum drained) even when Sanctuary blocks the quanta drain.
Is this by design? It goes against the wording of Black Hole. In analogous situations when the opponent doesn't have quanta, Black Hole doesn't heal.
Also, it creates strange situations where you'd be better off without Sanctuary than with it. For example, Gravity Nymph can pretty much exploit an opponent with Sanctuary for up to 24hp/turn. Without Sanctuary, at least the opponent would run out of quanta eventually, so the healing would stop. (Curse you, Dark Matter!)
(From this thread, it sounds like Nightmare has a similar side-effect, doing damage even if cards don't get added.
http://elementscommunity.org/forum/index.php/topic,21502.msg300002#msg300002)