According to the Wiki, Dark Matter has 12 Black Holes, which is a lot, but it is the Gravity Nymphs that allow him to do it every turn. You definitely want to either destroy or lobotomize the nymphs to stand a chance. Also, if you have any Novas or Cremations don't play them until the turn you will play the cards that need those quanta. A Lobotomizer helps a lot, because you can stop the nymphs, otyughs, and chargers.